Ralph Edward Hoffman MD

Professor of Psychiatry and Clinical Professor of Nursing; Medical Director, Intensive Outpatient Program at Yale-New Haven Psychiatric Hospital

Departments & Organizations

Yale Medical Group

Office of Student ResearchNIMH Research Training Program in Childhood-onset Neuropsychiatric Disorders | Albert J. Solnit Integrated Training | Psychiatry: Repetitive Transcranial Magnetic Stimulation Research Clinic; Adult PsychiatryGeneral Adult Intensive Outpatient Program; Dual Diagnosis Intensive Outpatient Program

Yale School of Nursing

Research Interests

Schizophrenia; Psychosis; Hallucinations; Delusions; Paranoia; Language; Pathophysiology; Neural network computer modeling; Transcranial magnetic stimulation; fMRI more...


  • B.S., Brown University, 1971
  • M.D., Albert Einstein College of Medicine, 1976

Selected Publications

  • Hoffman RE, Grasemann U, Gueorguieva R, Quinlan D, Lane D, Miikkulainen R. Using computational patients to evaluate illness mechanisms in schizophrenia. Biological Psychiatry 2011;69:997-1005
  • Hoffman, R.E, Pittman, B., Constable, R.T., Bhagwagar, Z., Hampson, M. Time-course of regional brain activity accompanying auditory/verbal hallucinations in schizophrenia. British Journal of Psychiatry 2011;198:277-283.
  • Hoffman, R.E., Fernandez, T., Pittman, B., Hampson, M. Elevated functional connectivity along a corticostriatal loop and the mechanism of auditory/verbal hallucinations in patients with schizophrenia. Biological Psychiatry 2011;69:407-14.



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